mbmm implements the Mechanistic Bayesian Mixture Model (MBMM) framework of Do, McCarthy, and Rogers (2026), A Mechanistic Bayesian Framework for Latent-State Inference in Vaccine and Infection Immunology.
MBMM infers posterior probabilities of latent immunological states, such as productive infection versus non-establishment or transient/abortive detection, or a boost-responsive versus weak/stable antibody phenotype, from sparse longitudinal biomarker trajectories.
The framework embeds an application-specific ordinary differential equation trajectory model inside a Bayesian mixture likelihood evaluated against Approximate Bayesian Computation (ABC) reference banks. Covariates are linked to latent-state probabilities through a logistic gate for two classes or a multinomial gate for more than two classes.
The package is deliberately domain-agnostic. Users supply the mechanistic trajectory model, ABC prior, observation model, and covariate data. mbmm supplies the shared inferential engine, including:
- ABC reference-bank construction;
- marginal reference-bank likelihoods;
- leave-one-donor-out scoring;
- logistic and multinomial gate fitting;
- likelihood-ratio and permutation tests;
- fitted-threshold estimation and uncertainty summaries;
- reduced manuscript-style simulation tools.
Installation
You can install the development version of mbmm from GitHub with:
# install.packages("remotes")
remotes::install_github("linhdo154/MBMM")Getting started
The Introduction to mbmm vignette walks through the main stages of an MBMM analysis: constructing reference banks, scoring subjects, and fitting the covariate-linked gate model using simulated correlate-of-protection data.
The reduced manuscript-style simulation vignette demonstrates how to generate synthetic cohorts and run the pipeline end to end.
The complete package website is available at:
Citation
To obtain the recommended package citation in R, run:
citation("mbmm")The methodological framework is described in:
Do, L., McCarthy, J., and Rogers, B. (2026).
A Mechanistic Bayesian Framework for Latent-State Inference in Vaccine and Infection Immunology.